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Last Updated: January 13, 2007

Developing the CTS-6

Dr. Brent Graham

Standardized criteria for the diagnosis of carpal tunnel syndrome: A synopsis of the development of the CTS-6

Overview

Our clinical experience indicated that unsatisfactory results after treatment for carpal tunnel syndrome could frequently be linked to an inaccurate initial diagnosis.  A review of the literature indicated that the diagnosis of carpal tunnel syndrome is often made according to highly variable criteria. A large number of internal medicine, surgical and primary care specialties treat the condition and it seemed possible that some of the variation might be specialty-specific.  In other words, the way in which a rheumatologist, an occupational health physician and a neurosurgeon diagnose carpal tunnel syndrome might vary substantially.  In addition, the use of electrodiagnostic tests in the overall evaluation of carpal tunnel also appeared to be highly variable.  While some clinical groups reported little or no role for electrodiagnostic tests, others considered this investigation to be the gold standard for the diagnosis of carpal tunnel syndrome.

We reasoned that the role of electrodiagnostic testing should be in adjusting the probability of carpal tunnel syndrome established clinically.  In a bayesian context, the clinical evaluation of carpal tunnel syndrome should allow the pre-test probability of carpal tunnel syndrome to be established.  Where this is intermediate, that is, neither very high or very low, an electrodiagnostic evaluation is indicated and should be used to modify the probability of carpal tunnel syndrome either up or down depending on the outcome of testing.  We tested this hypothesis on data published in the literature.  The results are shown in Figure. 
 

In the absence of widely accepted, standardized diagnostic criteria it is impossible to establish a valid estimate of the pre-test probability of carpal tunnel syndrome

The main objective of our work over the past five years has been to develop standardized criteria for the diagnosis of carpal tunnel syndrome.  These criteria have been identified and comprise a diagnostic instrument that we are naming the CTS-6.  Initial validation of this instrument has been completed.  Reliability studies are currently under design. 

For a more detailed communication of our findings read the synopsis:

Standardized criteria for the diagnosis of carpal tunnel syndrome: A synopsis of the development of the CTS-6

Supported by Physicians’ Service Foundation Grant 97-52

Related Publications:

Marx RG, Hudak PL, Bombardier C, Graham B, Goldsmith C, Wright JG. Related Articles
The reliability of physical examination for carpal tunnel syndrome.
J Hand Surg [Br]. 1998 Aug;23(4):499-502.
PMID: 9726554 [PubMed - indexed for MEDLINE]
 
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